PHARMACOLOGY OF 6,7-DIHYDROXY-2-DIMETHYLAMINOTETRALIN (TL-99) .1. CARDIOVASCULAR ACTIVITY IN DOG AND CAT

  • 1 January 1978
    • journal article
    • research article
    • Vol. 206  (2) , 239-247
Abstract
TL-99, the 5,6-dihydroxy isomer (M-7) and dopamine were studied for cardiovascular activity in the cat and dog. TL-99 was found to be the most active of these compounds. Some of the more striking actions of TL-99 and M-7 were bradycardia, hypotension and complete blockade of norepinephrine-induced reflex activation. A detailed study of these compounds showed that they were most likely exerting their effects by inhibiting sympathetic nervous system activity. Whether these compounds were activating dopamine receptors or .alpha.- adrenergic receptors was not entirely clear from this study.