EXPERIMENTAL AND CLINICAL INVESTIGATIONS ON THE PREGNANEDIOL EXCRETION IN HUMAN URINE

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Abstract
Urinary pregnanediol was determined by weighing after hydroyl-ysis, extraction and purification. Daily excretion was assayed in 5 normal women during 9 cycles. The total excretion, which occurred in the luteal phase only, varied from 34 to 53 mg and the maximum daily excretion was 8.5 mg. During pregnancy, there was a continual rise in pregnanediol excretion. No correlation could be shown between the pregnanediol values in the last few weeks before delivery and the onset of labor or the weight of the placenta. During puerperium, excretion fell to nil in the course of 3-6 days.

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