GLOMERULAR LESIONS IN PATIENTS WITH SCHISTOSOMA-HAEMATOBIUM INFECTION

  • 1 January 1978
    • journal article
    • letter
    • Vol. 30  (2) , 183-191
Abstract
The prevalence and type of glomerular lesions in patients with overt S. haematobium (S H) infection was investigated. Renal biopsies obtained from 13 patients were studied by light microscopy (in 13), ultra-structural (in 9) and immunofluorescence (in 11) techniques. Renal function was normal in all patients; only 2 had mild proteinuria. Glomerular deposits were absent in 4 patients. EM showed in 4 cases an increase of the mesangial matrix with subendothelial deposits in the mesangial area. Subepithelial deposits were also present in 1 of these cases. Associated or isolated deposits of IgM[immunoglobulin M], IgG[immunoglobulin G], C1q[q fragment of 1st complement component] and C3[3rd complement component] were identified in the glomeruli of 7 patients. Attempt to detect schistosomal antigen by using a high titer human anti-SH conjugate serum was unsuccessful. The relation between the glomerular lesions observed and schistosomiasis and other parasitic diseases is discussed.

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