Preparation of Glycyrrhetic Acid Glycosides Having Various .BETA.(1.RAR.2)-Linked Disaccharides and Their Cytoprotective Effects on Carbon Tetrachloride-Induced Hepatic Injury.

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Abstract
Glycyrrhetic acid glycosides (1-7) having β(1→2)-linked disaccharides such as 2-O-β-D-glucopyranosyl-β-D-galactopyranose, 2-O-β-D-galactopyranosyl-β-D-galactopyranose, 2-O-β-D-glucuronopyranosyl-β-D-galactopyranose, 2-O-β-D-glucopyranosyl-β-D-glucuronopyranose, 2-O-β-D-galactopyranosyl-β-D-glucuronopyranose, 2-O-β-D-galactopyranosyl-β-D-glucopyranose, 2-O-β-D-glucuronopyranosyl-β-D-glucopyranose, respectively, were synthesized by stepwise construction; from glucyrrhetic acid monoglycosides to the diglycosides. The cytoprotective activities of the glycosides 1-7 and 2-O-(β-D-glucopyranosyl)-β-D-glucopyranosyl-11-oxoolean-12-en-30-oate (8) were compared with natural occurring glycyrrhizin (9). Among these glycosides 1-8, glycosides 3 and 7 having β-D-glucuronopyranose (glcUA) as the only terminal sugar component were more effective materials against hepatic injury than glycyrrhizin 9.

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