Enabling the chemistry of life
- 11 January 2001
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 409 (6817) , 226-231
- https://doi.org/10.1038/35051697
Abstract
Enzymes are the subset of proteins that catalyse the chemistry of life, transforming both macromolecular substrates and small molecules. The precise three-dimensional architecture of enzymes permits almost unerring selectivity in physical and chemical steps to impose remarkable rate accelerations and specificity in product-determining reactions. Many enzymes are members of families that carry out related chemical transformations and offer opportunities for directed in vitro evolution, to tailor catalytic properties to particular functions.Keywords
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