The Effects of Allografts of Thymic Epithelial Reticular Cells on the Lymphoid Tissues of Neonatally Thymectomized Mice

Open Access
Publisher Website
Google Scholar
Abstract
Neonatal thymus placed in a Millipore diffusion chamber for one week loses its cortical cells, while the epithelial reticular cells remain viable. Grafts of these remnants in neonatally thymectomized mice are completely reconstituted from cells of the thymectomized host. Evidence is presented which suggests that the bone marrow may be a source of cells which reform the thymus cortex. These remnant grafts result in lymphoid reconstitution of neonatally thymectomized mice. The grafted animals also reject allografts of skin and lymphoma cells in a normal manner. However, these C3H mice, neonatally thymectomized and reconstituted with allografts of AKR thymic epithelial reticular cells, are tolerant to grafts of AKR lymphoma cells.

This publication has 1 reference indexed in Scilit: