IP 3 Receptor Types 2 and 3 Mediate Exocrine Secretion Underlying Energy Metabolism
- 30 September 2005
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 309 (5744) , 2232-2234
- https://doi.org/10.1126/science.1114110
Abstract
Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP3R2 and IP3R3) are intracellular calcium-release channels whose physiological roles are unknown. We show exocrine dysfunction in IP3R2 and IP3R3 double knock-out mice, which caused difficulties in nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands and the pancreas in the double mutants ascribed the secretion deficits to a lack of intracellular calcium release. Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP3R2 and IP3R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth.Keywords
This publication has 24 references indexed in Scilit:
- Homer 2 tunes G protein–coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activitiesThe Journal of cell biology, 2003
- Calcium signalling: dynamics, homeostasis and remodellingNature Reviews Molecular Cell Biology, 2003
- Salivary Acinar Cells from Aquaporin 5-deficient Mice Have Decreased Membrane Water Permeability and Altered Cell Volume RegulationJournal of Biological Chemistry, 2001
- Polarized Expression of Ca2+ Channels in Pancreatic and Salivary Gland CellsJournal of Biological Chemistry, 1997
- Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptorNature, 1996
- Intracellular channelsCurrent Opinion in Neurobiology, 1994
- Receptor-activated cytoplasmic Ca2+ spiking mediated by inositol trisphosphate is due to Ca2+-induced Ca2+ releaseCell, 1990
- Identification of Cellular Activation Mechanisms Associated with Salivary SecretionAnnual Review of Physiology, 1986
- Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphateNature, 1983
- Exaggerated Prandial Drinking in the Rat without Salivary GlandsNature, 1964