The Plasticity of Dendritic Cell Responses to Pathogens and Their Components
Top Cited Papers
- 26 October 2001
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 294 (5543) , 870-875
- https://doi.org/10.1126/science.294.5543.870
Abstract
Dendritic cells are involved in the initiation of both innate and adaptive immunity. To systematically explore how dendritic cells modulate the immune system in response to different pathogens, we used oligonucleotide microarrays to measure gene expression profiles of dendritic cells in response to Escherichia coli, Candida albicans, and influenza virus as well as to their molecular components. Both a shared core response and pathogen-specific programs of gene expression were observed upon exposure to each of these pathogens. These results reveal that dendritic cells sense diverse pathogens and elicit tailored pathogen-specific immune responses.Keywords
This publication has 27 references indexed in Scilit:
- Maturation of Human Monocyte-Derived Dendritic Cells Studied by Microarray HybridizationBiochemical and Biophysical Research Communications, 2000
- Immunobiology of Dendritic CellsAnnual Review of Immunology, 2000
- Surface Expression of HLA-E, an Inhibitor of Natural Killer Cells, Enhanced by Human Cytomegalovirus gpUL40Science, 2000
- Proteolysis and cell migration: creating a path?Published by Elsevier ,1999
- Reciprocal Control of T Helper Cell and Dendritic Cell DifferentiationScience, 1999
- High density synthetic oligonucleotide arraysNature Genetics, 1999
- A Fatal Relationship—Influenza Virus Interactions with the Host CellViral Immunology, 1999
- NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune ResponsesAnnual Review of Immunology, 1998
- Purification and Cloning of the GTP Cyclohydrolase I Feedback Regulatory Protein, GFRPPublished by Elsevier ,1996
- Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells.Journal of Clinical Investigation, 1994