Diagnosis of placental function by prediction curves for heat-stable alkaline phosphatase (HSAP).

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Abstract
Two expressions to predict HSAP [heat-stable alkaline phosphatase] values for their rise before 38.7 wk of gestation and declining after that were formulated. The expressions were loge y = 1.03a - 3.37 + 0.123x (i) and y = Y(1 + d/100) (ii), respectively. A chart of curves for these predicting expressions was prepared. In normal [human] pregnancies the deviation of prediction from measured values of HSAP was .+-. 15% in 94% of the cases examined. Many cases of abnormal pregnancy showed a low level of HSAP, -15% or lower, and abnormal signs in HSAP pattern were found several days or weeks prior to onset of fetal troubles. Prolonged pregnancy with fetal troubles was distinguishable from false prolonged pregnancy. In 2 consecutive pregnancies in the same woman, courses of HSAP were strikingly consistent as far as both pregnancies were normal. The placental production of HSAP and its release into the maternal blood may be influenced by the individual constant a in expression (i). The HSAP prediction curve was worthy to use as an easy screening method for placental function in the 3rd trimester of pregnancy.

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