Inhibition of Carbonic Anhydrase: Effect on Tissue Gas Tensions in the Rat
- 1 August 1958
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 98 (4) , 797-801
- https://doi.org/10.3181/00379727-98-24189
Abstract
The PCO2 of subcutaneous gas pockets in rats rose 8.6 mm Hg 30 minutes after carbonic anhydrase inhibition by acetazolamide (50 mg/kg intra-peritoneally). There was no change in PO2. There was an associated hyperventilation and 4 vol. percent rise in arterial CO2 content. Control studies showed no change. Results are interpreted as evidence of a rise in venous and tissue PCO2 following carbonic anhydrase inhibition.Keywords
This publication has 1 reference indexed in Scilit:
- Gas Transfers in a Sulfur Hexafluoride PneumoperitoneumJournal of Applied Physiology, 1953