Soft-tissue uptake of99m-Tc-diphosphonate and99mTc-pyrophosphate in amyloidosis

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Abstract
This study describes the results of scintigraphy with99mTc-labeled methylene-diphosphonate (99mTc-MDP) and pyrophosphate (99mTc-PYP) as a noninvasive test for the distribution of organ involvement in five different types of amyloidosis. Scintigraphy with99mTc-labeled phosphates appeared to be a sensitive noninvasive screening test for the extent and the distribution of organ involvement in systemic AA and systemic AL amyloidosis as well as in local bronchial amyloid, local dermal amyloid, and familial amyloidotic polyneuropathy. Echocardiography, however, was more sensitive for demonstrating cardiac involvement in systemic amyloidosis than99mTc-MDP or99mTc-PYP scintigraphy.99mTc-MDP images showed a better contrast than99mTc-PYP images, although there was no difference in. the extent or the intensity of soft-tissue uptake.