Enhanced Cellular Uptake of G-Rich Oligonucleotides

1 May 1995

journal article
Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids

Vol. 14 (3) , 1077-1081
https://doi.org/10.1080/15257779508012538

Abstract

Sequence-dependency of cellular uptake of oligonucleotides into Vero cells has been studied. Cellular uptake of 5′-[³⁵S]-labelled homopolymers decreased in the order (dG)₁₆ >> (dT)₁₆> (dA)₁₆ > (dC)₁₆. The change of two base-pairs (dG → dA) in a dG-rich antisense oligonucleotide with good antiviral activity dramatically decreased cellular uptake and abolished antiviral activity.

Keywords

ANTIVIRAL
OLIGONUCLEOTIDES
CELLULAR UPTAKE
GOOD
RICH
VERO
35S

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