Methandrostenolone and nandrolone decanoate in muscular dystrophy

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Abstract
The results are reported of a double-blind controlled trial in which 38 patients with muscular dystrophy (10 with Duchenne-type dystrophy, 9 with limb-girdle dystrophy, 9 with facioscapulohumeral dystrophy, and 10 with dystrophia myotonica) were treated with nandrolone decanoate or with methandrostenolone. The results of treatment with the active remedies given over a 3-month period were compared with the results of treatment with an inert control remedy. No significant improvement, subjective or objective, was seen in patients receiving the active remedies, except for the fact that in adult patients particularly there was a significant increase in body weight and appetite. No significant increase in muscular power or in functional capacity occurred. There is no indication for the routine use of these expensive remedies in patients with muscular dystrophy.

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