The Tranquilizing Efficacy of Ethchlorvynol (Placidyl) in Dermatological Therapy

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Abstract
This report deals with the clinical evaluation of ethchlorvynol* (ethyl β-chlorovinylethynylcarbinol; Placidyl) a new nonbarbiturate tranquilizing agent, structurally different from the others that are available at this time.1,2 Its pharmacological action is similar to that produced by the barbiturates but has the advantage of absence of respiratory depression and initial states of excitement which are sometimes seen after the administration of barbiturates. The structure of ethchlorvynol is chemically unrelated to that of the barbituric acid derivatives. There is no chemical relationship to other sedatives such as chloral hydrate, bromides, and paraldehyde. This clinical investigation included a series of 180 patients with various dermatoses in whom there was an uncontrollable urge to scratch or in whom a tension factor contributed to the cutaneous disorder, including atopic dermatitis, urticaria, neurodermatitis, anogenital pruritus, prurigo nodularis, dermatitis herpetiformis, chronic lichenoid and discoid exudative dermatitis, exfoliative dermatitis,

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