Relationship between the HLA Associated Specificities 4a and 4b and the Lymphocyte C3 Receptor

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Abstract
Antisera to 4a and 4b apparently do not specifically inhibit C3 [complement component 3] rosette formation by human lymphocytes. Pretreatment of lymphocytes with various whole 4a and 4b antisera resulted in partial inhibition which was often nonspecific. Ultracentrifugation of the sera to remove immune complexes removed C3 rosette inhibitory activity although specific cytotoxic activity remained. It is probable that immune complexes in antisera will have fixed C3 which will have been converted to C3d and so be able to block the C3d receptor. This is the receptor mainly measured in these and in the previous experiments.