Anti-Inflammatory Compounds of Plant Origin. Part I. Action on Arachidonic Acid Pathway, Nitric Oxide and Nuclear Factor κ B (NF-κB)
- 1 November 2003
- journal article
- review article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 69 (11) , 973-983
- https://doi.org/10.1055/s-2003-45141
Abstract
Over the last 10 years, a significant body of evidence has emerged indicating that chemically diverse classes of naturally-occurring substances derived from higher plants are of potential interest for therapeutic interventions in several inflammatory diseases. Part I of this review article focuses on our current knowledge of the mechanisms by which a large range of plant-derived constituents interfere with three relevant targets involved in the inflammatory process, namely arachidonic acid metabolite pathways, nitric oxide and NF-κB, and discusses their potential therapeutic use in the management of relevant inflammatory diseases. AP-1:activator protein-1 CAPE:caffeic acid phenethyl ester COX:cyclooxygenase ELAM-1:endothelial-leukocyte adhesion molecule-1 ICAM-1:intercellular adhesion molecule-1 IL:interleukin iNOS:inducible nitric oxide synthase LO:lipoxygenase LPS:lipopolysaccharide LT:leukotriene MPO:myeloperoxidase NF-κB:nuclear factor kappa B NO:nitric oxide PGE2:prostaglandin E2 TXA2:thromboxane A2 PLA2:phospholipase A2 PKC:protein kinase C PMA/TPA:phorbol myristate acetate TGF-β1:transforming growth factor-β1 TNF-α:tumour necrosis factor CAM-1:vascular cell adhesion molecule-1Keywords
This publication has 0 references indexed in Scilit: