TREATMENT OF ANGINA PECTORIS WITH BETA‐RECEPTOR BLOCKADE, MODE OF ACTION

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Abstract
In a double‐blind, cross‐over study, the effect of the dextro isomer and the racemate of a beta‐receptor blocking agent (H56/28®) was compared with that of a placebo in 13 patients with angina pectoris. The dextro isomer had no effect on attack rate. The inhibitive effect of racemate on angina pectoris was highly significant statistically. The decrease in the number of angina pectoris attacks was of such magnitude that it was considered also of clinical significance in the majority of the patients. The difference in effect of the dextro isomer and of the racemate indicates that the inhibitive effect on angina pectoris is due to the laevo isomer. The main beta‐receptor blocking activity resides in the laevo isomer and, thus, the beneficial effect on angina pectoris seems to be due to beta‐receptor blocking properties. No definitely serious side‐effects were observed.