CORTICOSTEROIDS SUPPRESS PLASMINOGEN ACTIVATION IN THE BOVINE SERTOLI CELL
- 1 January 1986
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 108 (1) , R1-R3
- https://doi.org/10.1677/joe.0.108r001
Abstract
Bovine FSH stimulated a six fold increase in secretion of plasminogen activator by immature bovine Sertoli cells with half-maximum response (ED50) at 145ng/ml. Treatment with FSH and either dexamethasone, cortisol or corticosterone produced a dose-dependent suppression of PA activity, with ED50 values of 35, 320 and >650nmol/l respectively. Effects of dexamethasone required over 6 h incubation to become significant (P < 0.001), and were blocked by inhibitors of RNA synthesis and translation. These data demonstrate direct effects of corticosteroids on Sertoli cells, resulting in the synthesis of antiprotease factors which antagonize the actions of FSH.This publication has 11 references indexed in Scilit:
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