Inclusion body myositis: genetic factors, aberrant protein expression, and autoimmunity
- 1 November 2001
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Rheumatology
- Vol. 13 (6) , 469-475
- https://doi.org/10.1097/00002281-200111000-00003
Abstract
Sporadic inclusion body myositis (s-IBM) is an inflammatory myopathy mainly affecting elderly individuals. It has a chronic progressive course leading to severe disability. Immunosuppressive treatment is in most instances ineffective. S-IBM is morphologically characterized by mononuclear cell infiltrates and vacuolated muscle fibers with pathologic accumulation of a large number of different proteins. Recent research has focused on the expression of various factors that may contribute to the inflammatory reaction and the typical inclusions. This review summarizes the new information on genetic factors, abnormal protein expression and inflammation, which provides a basis for linking the different typical morphologic features of s-IBM to a cascade of pathogenic events.Keywords
This publication has 61 references indexed in Scilit:
- A controlled study of intravenous immunoglobulin combined with prednisone in the treatment of IBMNeurology, 2001
- Report of a patient with inclusion body myositis and CD8+ chronic lymphocytic leukaemia - post-mortem analysis of muscle and brainActa Neurologica Scandinavica, 2001
- Inclusion-Body Myositis: Newest Concepts of Pathogenesis and Relation to Aging and Alzheimer DiseaseJournal of Neuropathology and Experimental Neurology, 2001
- Disease progression in sporadic inclusion body myositis: Observations in 78 patientsNeurology, 2000
- Novel Immunolocalization of α-Synuclein in Human Muscle of Inclusion-Body Myositis, Regenerating and Necrotic Muscle Fibers, and at Neuromuscular JunctionsJournal of Neuropathology and Experimental Neurology, 2000
- Paired Helical Filaments of Inclusion-Body Myositis Muscle Contain RNA and Survival Motor Neuron ProteinThe American Journal of Pathology, 2000
- Treatment of inclusion body myositisCurrent Opinion in Rheumatology, 1999
- Inclusion body myositis and myopathiesAnnals of Neurology, 1995
- β‐Amyloid precursor epitopes in muscle fibers of inclusion body myositisAnnals of Neurology, 1993
- Amyloid Filaments in Inclusion Body MyositisArchives of Neurology, 1991