Pharmacological Studies on Crude Drugs. VI

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Abstract
Various properties of essential oil of plants were examined with essential oil of eight kinds of Lauraceae plants and standard samples of various essential oils. Separation of each component by gaschromatography, identification, and quantitative determination were carried out, as well as the examination of various pharmacological effects on circulation system, such as the action of samples on the excised heart of a toad, rabbit heart, rabbit respiration and blood pressure, and on blood vessels of toad hind legs.Essential oil was separated well into each component by gas chromatography, using polyethylene glycol 6000 and silicone DC 200 as the stationary phase and determination was made in comparatively high accuracy. The components obtained agreed well with those given in the past literature but there were few discrepancies.In pharmacological test, these essential oils were generally inhibitive and depressive against heart and blood pressure, but the action was weak in camphor and the essential oil from the camphor tree, some of which showed acceleration of the heart action and elevation of blood pressure. In the perfusion test of toad hind leg, non-water-soluble factor of the essential oil seemed to have a grave effect on the test and physiological action of the essential oils could not be confirmed.

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