Abstract
Half the risk of ischaemic stroke remains unexplained by conventional risk factors1 and genetic predisposition has been widely speculated to account for some of this unexplained risk.2 Although significant progress has been made unravelling the basis of single gene stroke disorders, identifying the underlying genes for common or multifactorial stroke, for which there is no obvious Mendelian pattern of inheritance, has proved difficult. Has this situation changed with the recent publication of the first independent risk gene for common stroke?3

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