Platinum complexes with binding affinity for the estrogen receptor
- 1 September 1988
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 31 (9) , 1675-1679
- https://doi.org/10.1021/jm00117a002
Abstract
A number of (1,2-diaminoethane)dichloroplatinum(II) complexes, linked to dihydroxy-2-phenylindole by spacer groups of varying lengths, were synthesized and studied for their binding affinities for the calf uterine estrogen receptor. Best binding conditions were provided by the n-hexyl and the p-xylene group as spacer with RBA values of 6.5 (16c) and 4.4 (17c), respectively (17.beta.-estradiol: RBA = 100). These values are only slightly lower than those of the corresponding diaminoethane ligands.This publication has 3 references indexed in Scilit:
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