Intravenöse Immunglobulinsubstitution bei Antikörpermangelsyndrom

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Abstract
Seven patients received a total of 23 infusions of a polyvalent largely monomeric and intravenously applicable Ig preparation (Sandoglobulin). Among them are 2 with congenital antibody deficiency syndrome. One of them, who has agammaglobulinemia type Bruton, is still receiving 9 g Sandoglobulin every 3 mo. During the now 40-wk period of observation the IgG serum level has remained adequately high and the patient has had no infection; half-life of the Sandoglobulin is 32.4 days. In the other patient, with recently diagnosed hyper-IgM syndrome, 6 g Sandoglobulin were administered every month or every 2nd month. During an observation period of 44 wk he had no further infections. The initially much increased IgM serum level (16 g/l) slowly but definitely fell during substitution to 9 g/l at the end of the observation; half-life of Sandoglobulin is 34.1 days. All 23 Sandoglobulin infusions were given without side effects.

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