HB Tunis [α2β2124(H2) PRO→SER], A New β Chain Variant Identified by HPLC
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Hemoglobin
- Vol. 12 (1) , 23-30
- https://doi.org/10.3109/03630268808996879
Abstract
During a routine hematological investigation of a child from Tunis, [Tunisia] a silent hemoglobin variant was discovered by isoelectric-focusing. This variant was not detectable by conventional electrophoretic methods, had normal stability, expression, and oxygen affinity, and did not produce any clinical symptoms. This new variant .beta.124(H2)Pro-Ser was named Hb Tunis.This publication has 12 references indexed in Scilit:
- High Performance Liquid Cbromatographic Separation of Globin Chains on a Large-Pore C4ColumnJournal of Liquid Chromatography, 1984
- A Silent, Neutral Substitution Detected by Reverse-Phase High-Performance Liquid Chromatography: Hemoglobin BeirutScience, 1983
- Separation of phenylthiohydantoin—amino acids by high-performance liquid chromatographyJournal of Chromatography A, 1983
- Globin Chain Electrophoresis: a New Approach to the Determination of the Gγ/Aγ Ratio in Fetal Haemoglobin and to Studies of Globin SynthesisBritish Journal of Haematology, 1980
- Isoelectric focusing of human hemoglobin: its application to screening, to the characterization of 70 variants, and to the study of modified fractions of normal hemoglobinsBlood, 1978
- Hemoglobin Ty gard (αA2β2 124 (H2) Pro → Gln) a stable high O2 affinity variant at the α1β1 contactFEBS Letters, 1978
- Human embryonic haemoglobins including a comparison by homology of the human ζ and α chainsNature, 1975
- A Simple Method for the Detection of Unstable HaemoglobinsBritish Journal of Haematology, 1972
- Abnormal human haemoglobins: Separation and characterization of the α and β chains by chromatography, and the determination of two new variants, Hb chesapeake and Hb J (Bangkok)Journal of Molecular Biology, 1966
- Estimation of Small Percentages of Fœtal HæmoglobinNature, 1959