Short-Term Zinc Deficiency and Hemostasis in the Rat

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Abstract
Immature male rats fed a soybean protein-based diet containing < 1 ppm of Zn showed a 50% reduction of plasma Zn within 2 days and an increased saline bleeding time within 4 days. Administration of a single dose (10 .mu.g/kg body wt) of Zn intragastrically restored bleeding time to normal within 4 h and this was associated with increased plasma Zn concentration. A larger dose (100 .mu.g/kg) restored the bleeding time of deficient rats to normal but increased the bleeding time of controls fed adequate Zn. This pharmacological effect in controls was largely dissipated after 8 h but the repleted animals maintained the normal bleeding time during this period. Consumption of a low-Zn diet rapidly induces a bleeding tendency which is closely related to plasma Zn concentration. Extracellular Zn apparently plays a significant role in hemostasis.

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