Metabolism of magnesium in central nervous system

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Abstract
Deprivation of magnesium in the diet of rats rapidly induced a net loss of magnesium from the central nervous system. During progressive magnesium deficiency, a low magnesium concentration in cerebrospinal fluid (CSF) indicated that magnesium also was decreased in the brain. After parenteral administration of magnesium, CSF and skeletal muscle magnesium promptly returned to normal, but the correction of cellular deficits in the brain required several hours. Complete restoration of magnesium losses occurred within two hours in cerebral cortex and cerebellum and within four to six hours in the diencephalon-midbrain and pons-medulla. The most important factor in the difference between predominantly gray and predominantly white matter was that the loss of magnesium was greater from predominantly white matter.

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