Enantioselective furylation of prochiral aldehydes by difurylzinc in the presence of a chiral amino alcohol: asymmetric synthesis of 2-furylmethanols
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- Vol. 22 (11) , 3214-3215
- https://doi.org/10.1039/p19900003214
Abstract
The first example of the enantioselective furylation of aldehydes is described. Optically active 2-furylmethanols have been synthesized in good enantiomeric excesses (up to 73% e.e.) by the enantioselective addition of difurylzinc to aldehydes using N,N-dibutylnorephedrine and N,N-di(4-phenylbutyl)norephedrine as either chiral ligands or catalysts.Keywords
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