Selective Elevation of Monocyte Chemotactic Protein-1 in the Cerebrospinal Fluid of AIDS Patients with Cytomegalovirus Encephalitis
Open Access
- 1 November 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 174 (5) , 1098-1100
- https://doi.org/10.1093/infdis/174.5.1098
Abstract
The CC chemokine monocyte chemotactic protein-1 (MCP-1) was markedly elevated in the cerebrospinal fluid (CSF) of human immunodeficiency virus (HIV)-infected patients with cytomegalovirus (CMV) encephalitis. The MCP-l CSF levelsin CMVencephalitis weremarkedly higher than those in the CSF of HIV-infected patients with or without unrelated neurologic diseases, including progressivemultifocal leukoencephalopathy, cryptococcalmeningitis, toxoplasmic encephalitis, and primary lymphoma. Interleukin-8, RANTES, macrophage inflammatory protein (MIP)-1α, and MIP-1β were not substantially increased in the CSF of CMV encephalitis patients. High levels of MCP-1 may underlie monocyte recruitment and tissue damage in CMV encephalitis and may represent a rapid and useful tool in the diagnostic armamentarium for neurologic disorders associated with HIV infection.Keywords
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