RENAL TUBULAR SECRETION OF POTASSIUM IN MAN 1

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Abstract
Data are presented to show that K is actively secreted by the renal tubules of man. This was demonstrated in several persons suffering from far advanced renal insufficiency in whom the clearance of K regularly exceeded the simultaneous clearance of endogenous creatinine. Ratios of K excreted to that filtered through the glomeruli ranged from 1.2 to 2 and were not depressed in one subject by the admn. of caronamide. This tubular secretion of K acted as a mechanism preventing toxic accumulation of K in the body fluids of these cases; however, it also contributed to a deficiency of body K in some instances.