Leucocyte Glutamate Dehydrogenase in Various Hereditary Ataxias
- 1 August 1980
- journal article
- research article
- Published by Cambridge University Press (CUP) in Canadian Journal of Neurological Sciences
- Vol. 7 (4) , 421-424
- https://doi.org/10.1017/s031716710002299x
Abstract
Leucocyte Glutamate Dehydrogenase (GDH) activity was measured in 44 patients with various forms of ataxia and 44 age and sex-matched normal controls. The only significant change found was a moderate decrease in activity in Freidreich's ataxia and a few patients with OPCA. This decreased activity is not primary to the disease but probably reflects a regulatory defect affecting mitochondrial membranes in these patients.This publication has 15 references indexed in Scilit:
- Glutamate dehydrogenase deficiency in three patients with spinocerebellar syndromeAnnals of Neurology, 1980
- Regional Distribution of Amino Acids in Friedreich's Ataxia BrainsCanadian Journal of Neurological Sciences, 1979
- Concentrations of glutamic acid in cerebellar cortex and deep nuclei of normal mice and weaver, staggerer and nervous mutantsBrain Research, 1978
- Autosomal Recessive Spastic Ataxia of Charlevoix-SaguenayCanadian Journal of Neurological Sciences, 1978
- Aspartate‐taurine imbalance in dominantly inherited olivopontocerebellar atrophyNeurology, 1977
- Electrophoresis of human L-glutamate dehydrogenase: Tissue distribution and preliminary population surveyBiochemical Genetics, 1977
- Clinical Description and Roentgenologic Evaluation of Patients with Friedreich's AtaxiaCanadian Journal of Neurological Sciences, 1976
- CONTENTS OF SEVERAL AMINO ACIDS IN THE CEREBELLUM, BRAIN STEM AND CEREBRUM OF THE ‘STAGGERER’, ‘WEAVER’ AND ‘NERVOUS’ NEUROLOGICALLY MUTANT MICE1Journal of Neurochemistry, 1976
- Glutamate Dehydrogenase UV-AssayPublished by Elsevier ,1974
- DISTRIBUTION OF SOME ENZYMES ASSOCIATED WITH THE METABOLISM OF GLUTAMATE, ASPARTATE, γ‐AMINOBUTYRATE AND GLUTAMINE IN CAT SPINAL CORD1Journal of Neurochemistry, 1969