Cellular Immunity in Renal Diseases

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Abstract
Cellular immune reactivity was studied in 78 patients with various forms of renal disease by skin testing with 4 recall antigens and a lymphocyte transformation test with tuberculin PPD [purified protein derivative] and leukoagglutinin. Patients with S-creatinine .gtoreq. 230 .mu.M and those with chronic pyelonephritis who had S-creatinine values below 230 .mu.M had significantly lower skin reactions than the controls to streptokinase-streptodornase, parotitis and PPD. Glomerulonephritic patients with S-creatinine values below 230 .mu.M had normal skin reactivity. Lymphocyte transformation tests showed decreased reactivity only in patients with S-creatinine level .gtoreq. 230 .mu.M. An association of chronic pyelonephritis with a defective efferent, nonspecific arm of cellular immunity was suggested.