Evaluation of Adrenocortical Function with Intramuscular Injection of ACTH Gel

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Abstract
THE response of the adrenal cortex to intensive stimulation with exogenous ACTH provides an excellent guide to the functional status of the adrenal cortex under most circumstances. Tests based on this principle have recently been improved and made more reliable by the development of fairly specific methods for the measurement of hydrocortisone and some of its metabolites in the blood and urine. Jenkins et al.1 have clearly demonstrated that the determination of 17-hydroxycorticosteroids in urine after ACTH stimulation is a more sensitive index of adrenocortical responsiveness than urinary 17-ketosteroids, and is a more direct and specific index than changes in . . .