Experimental Assessment of Epileptogenesis in the Monkey Cerebral Cortex

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Abstract
Introduction In previous studies French, Gernandt, and Livingston11 observed that upon direct repetitive stimulation different areas of the monkey's cerebral cortex displayed different thresholds for the induction of electrical after-discharges. The motor cortex had the lowest and the occipital the highest threshold for seizure induction with this technique. A subsequent study by Eidelberg, Konigsmark, and French9 revealed that this differential susceptibility to seizure induction was paralleled by differences in the amplitude of the direct cortical responses (DCR) to single-shock local electrical stimulation. The maximum amplitudes were encountered in the motor cortex, while minimum deflections were found in the occipital cortex; intermediate values were present in other areas of the convexity. Recently Kandel, Spencer, and Brinley18 have reported very large responses to be elicited by a similar technique on the dorsal hippocampal surface, one of the most epileptogenic structures. Chang,5,6 Clare and Bishop,7 and others have

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