Percutaneous absorption of .ALPHA.-olefin sulfonate (AOS) in rats.

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Abstract
Percutaneous absorption of .alpha.-olefin sulfonate (AOS) [enviromental pollutent] was investigated in rats by using 14C-labeled compound. The solution of 14C-AOS was applied to the dorsal skin under various conditions: (a) the intact skin dried naturally after application, (b) the intack skin wiped off 0.5 h after application, (c) the intact skin wiped off 1.5 h after application, (d) the intact skin with a plastic cup containing 14C-AOS solution and (e) the damaged skin without the stratum corneum dried naturally after application. When rats were applied with 0.5 ml of a 0.2% solution of 14C-AOS under the condition of (a), the recoveries of radioactivity were 0.33% in the urine, 0.08% in the bile and 0.21% in the main organs [brain, lung, liver, kidney, spleene] at 24 h after application. The total amount absorbed through the skin was about 0.6% of the applied dose. Comparing the results obtained under the conditions of (a), (b) and (c), the percutaneous absorption of 14C-AOS applied on the skin was almost finished by 1.5 h after application. The excretion of radioactivity into the urine and bile was approached to the highest rate around 3-6 h, then gradually decreased, and continued even 70-90 h after application. When a 0.02% solution of 14C-AOS was always in contact with the skin under the condition of (d), a small amount of the surfactant was continuously absorbed from the skin. When the skin was damaged and 14C-AOS was applied on it under the condition of (e), a greater amount of radioactivity was excreted into the urine and bile, and the recoveries were 36.26% in the urine, 1.83% in the bile and 12.28% in the main organs 30 h after application, being about 50% in total.

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