Substance P modulates taste responses in the nucleus of the solitary tract of the hamster
- 1 May 1997
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 8 (7) , 1723-1727
- https://doi.org/10.1097/00001756-199705060-00031
Abstract
THE effects of substance (SP) microinjections on the electrophysiological response of gustatory neurons within the nucleus of the solitary tract (NST) were examined in hamsters following either anodal electrical or NaCl stimulation of the anterior tongue. For both types of stimulation, SP produced excitatory and suppressive effects on the activity of gustatory NST neurons, with excitatory effects being more common. In response to repetitive anodal stimulation of the tongue, the modulatory effect of SP lasted 30–400 s. In the presence of SP, the firing rate of 48% of the neurons was increased and that of 9% was decreased following NaCl stimulation. This dual action of SP could be due to direct excitation of taste-responsive neurons and to excitation of inhibitory local circuit neurons which, in turn, decrease the responsiveness of gustatory neurons.Keywords
This publication has 18 references indexed in Scilit:
- GABA-like immunoreactivity in the gustatory zone of the nucleus of the solitary tract in the hamster: Light and electron microscopic studiesBrain Research Bulletin, 1993
- Gustatory innervation in the rabbit: Central distribution of sensory and motor components of the chorda tympani, glossopharyngeal, and superior laryngeal nervesJournal of Comparative Neurology, 1989
- Tyrosine hydroxylase-like and dopamine β-hydroxylase-like immunoreactivity in the gustatory zone of the nucleus of the solitary tract in the hamster: Light- and electron-microscopic studiesNeuroscience, 1988
- The organization of taste sensibilities in hamster chorda tympani nerve fibers.The Journal of general physiology, 1988
- The gustatory zone of the nucleus of the solitary tract in the hamster: light microscopic morphometric studiesChemical Senses, 1986
- Central projections of gustatory nerves in the ratJournal of Comparative Neurology, 1984
- The central projections of the trigeminal, facial, glossopharyngeal and vagus nerves: an autoradiographic study in the ratJournal of the Autonomic Nervous System, 1982
- A metric for the breadth of tuning of gustatory neuronsChemical Senses, 1979
- An autoradiographic examination of the central distribution of the trigeminal, facial, glossopharyngeal, and vagal nerves in the monkeyJournal of Comparative Neurology, 1979
- An Analysis of Hamster Afferent Taste Nerve Response FunctionsThe Journal of general physiology, 1973