Liver and gall-bladder imaging with Technetium-99m dihydrothioctic acid and Technetium-99m pyridoxylidene glutamate—a study in the young pig

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Abstract
Scans [17] were performed on 10 young pigs after injection of Tc-99m labeled dihydrothioctic acid (99Tcm-DHT) and 99Tcm-labeled pyridoxylidene glutamate (99Tcm-PG) using a gamma-camera. Sequential images of the liver, gall bladder and intestine were observed in all healthy animals. 99Tcm-DHT produced the clearer liver images, whereas 99Tcm-PG produced more rapid and intense gall bladder images. Analysis of hepatic bile in 3 animals suggested a more rapid and higher concentration of 99Tcm-PG than 99Tcm-DHT (36% vs. 4% of the injected dose over 2 h). Bowel images were not seen in an animal that had undergone excision of the extrahepatic biliary tract, but scans performed after hepaticojejunostomy demonstrated intestinal transit of isotope. The hepatobiliary system can be easily imaged using 99Tcm-labeled compounds which were excreted into bile. These agents may be useful in the diagnosis of obstructive lesions of the extrahepatic biliary tract of adults and infants [human].
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