TOXICITY STUDIES OF THE TOXINS ISOLATED FROM ANNUAL RYEGRASS (LOLIUM RIGIDUM) INFECTED BY CORYNEBACTERIUM RATHAYI
- 1 February 1982
- journal article
- research article
- Published by Wiley in Immunology & Cell Biology
- Vol. 60 (1) , 129-132
- https://doi.org/10.1038/icb.1982.13
Abstract
Estimates of the LD50's of 7 glycolipid toxins (corynetoxins) isolated from toxic annual ryegrass varied in the range 01–13 mg/kg in 2-week-old rats. The delay in onset of neurological signs in rats and sheep was independent of dose rate and could be the result of inhibition of protein biosynthesis. In sheep, no influence of the route of administration on the delay in onset of neurological signs was demonstrated. The relationship between the partial structures of the two major corynetoxins and their toxicity is discussed.Keywords
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