Estrogen Antagonisms: Inhibition of Estrone-Induced Uterine Growth by Testosterone Propionate, Progesterone and 17-ethyl-19-nortestosterone
- 1 March 1957
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 94 (3) , 537-539
- https://doi.org/10.3181/00379727-94-23004
Abstract
When given in combination with a 0.3 ug dose of estrone to intact, immature mice these 3 compounds caused a reduction in uterine growth expected from the estrone itself. This depression of response can be described satisfactorily with straight log dose-response lines. Progesterone had about 1.4 times and 17-ethyl-19-nortestosterone had about 70 times the antiestrogenic potency of testosterone propionate. This high activity of 17-ethyl-19-nortestosterone did not appear to correlate with androgenic, anabolic, pro-gestational or metrotropic properties.Keywords
This publication has 0 references indexed in Scilit: