To establish therapeutic guidelines, benoxaprofen [an antiinflammatory agent] kinetics were examined in 26 adult subjects with normal and decreased renal function. Mean peak plasma concentrations after a single 600-mg dose ranged from 58-72 mg/l, independently of renal function. Elimination half-life and benoxaprofen plasma clearance correlated with creatinine clearance. Hemodialysis did not remove benoxaprofen from plasma. A dosage nomogram was derived from which a dose 1/2 of the normal maintenance dose was suggested for patients with severe renal failure.