Effect of LATS, TSH and cholera toxin on the thyroid gland in nude mice.
- 1 January 1977
- journal article
- research article
- Published by Japan Endocrine Society in Endocrinologia Japonica
- Vol. 24 (3) , 277-280
- https://doi.org/10.1507/endocrj1954.24.277
Abstract
Three thyroid stimulators, LATS [Long Acting Thyroid Stimulator], TSH [thyrotropin] and cholera toxin, were tested by bioassay using congenitally athymic homozygous mice (nu/nu), nude mice and control littermates (nu/+) possessing normal thymic function. nu/+ Animals showed a response to LATS similarly to normal white mice of the ddN strain. The assay response to LATS in nu/nu animals was about 1/2 that in normal mice. TSH also showed a less stimulating action in nude mice. Cholera toxin made a long acting response similarly to LATS. The response to cholera toxin in nude mice was about 1/2 that of normal control mice. The thyroid of nude mice has a receptor for LATS-immunoglobulin, TSH or cholera toxin, which is similar to that of normal mice.This publication has 3 references indexed in Scilit:
- Cholera toxin interactions with thyrotropin receptors on thyroid plasma membranes.Proceedings of the National Academy of Sciences, 1976
- THE PRESENCE OF AN ABNORMAL THYROIDSTIMULATING HORMONE IN THE SERUM OF SOME THYROTOXIC PATIENTS*Journal of Clinical Endocrinology & Metabolism, 1958
- DELAYED THYROID RESPONSE TO SERUM FROM THYROTOXIC PATIENTSEndocrinology, 1958