Roots: Mutation frequency decline revisited
- 1 June 1994
- Vol. 16 (6) , 437-444
- https://doi.org/10.1002/bies.950160613
Abstract
‘Mutation frequency decline’ (MFD) was discovered about forty years ago, and described as the disappearance of a particular class of ultraviolet light‐induced mutations in Escherichia coli that occurred whenever protein synthesis was briefly inhibited immediately after irradiation. Later, MFD was interpreted as an excision repair anomaly uniquely affecting nonsense suppressor mutations induced in certain tRNA genes. Never fully understood, MFD has recently been linked to the newly discovered transcription‐coupled rapid repair of ultraviolet damage on the templat strand of active genes. This article recalls the emergence and development of the MFD story, and offers a new way to explain it and its relation to strand‐specific excision repair.Keywords
This publication has 35 references indexed in Scilit:
- DNA mismatch repair-induced double-strand breaksDNA Repair, 2007
- Ultraviolet light-induced responses of an mfd mutant of escherichia coli B/r having a slow rate of dimer excisionMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1975
- Ultraviolet action spectra for mutation in Escherichia coliMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1970
- Characterization of revertants of E. coli WU36-10 and WP2 using amber mutants and an ochre mutant of bacteriophage T4Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1967
- Mutation in Escherichia coli B/r WP2 try− by reversion or suppression of a chain-terminating codonMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1967
- Radiation-Induced Mutations and Their RepairScience, 1966
- Photoreversal and “dark repair” of mutations to prototrophy induced by ultraviolet light in photoreactivable and non-photoreactivable strains of Escherichia coliMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1964
- Thymin-dimerisierung und Überlebensrate bei bakterienJournal of Molecular Biology, 1962
- Disappearance of thymine photodimer in ultraviolet irradiated DNA upon treatment with a photoreactivating enzyme from Baker's yeastBiochemical and Biophysical Research Communications, 1962
- Modification of mutagenesis initiated by ultraviolet light through posttreatment of bacteria with basic dyesJournal of Cellular and Comparative Physiology, 1961