Relation between hormone replacement therapy and ischaemic heart disease in women: prospective observational study

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Abstract
What is already known on this topic What is already known on this topic Observational studies have shown that hormone replacement therapy protects women against ischaemic heart disease Randomised clinical trials found no such effect Little attention has focused on identifying subgroups of women who would or would not benefit from treatment What this study adds What this study adds Hormone replacement therapy does not protect against ischaemic heart disease Women with diabetes who use hormone replacement therapy are at an increased risk of death from all causes and ischaemic heart disease What is already known on this topic What is already known on this topic Observational studies have shown that hormone replacement therapy protects women against ischaemic heart disease Randomised clinical trials found no such effect Little attention has focused on identifying subgroups of women who would or would not benefit from treatment What this study adds What this study adds Hormone replacement therapy does not protect against ischaemic heart disease Women with diabetes who use hormone replacement therapy are at an increased risk of death from all causes and ischaemic heart disease