A correlation of toxicity of albendazole and oxfendazole with their free metabolites and bound residues

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Abstract
The possible correlations between embryotoxicity, plasma kinetics of toxic metabolites and covalent binding of metabolites to fetal tissues were studied using 2 drugs, albendazole and oxfendazole [antihelminthics]. In the rat, the metabolic inhibitor, SKF-525-A [proadifen hydrochloride], induced changes in embryotoxicity which were well correlated with plasma levels of identified embryotoxic metabolites, but not with the levels of fetal tissue-bound drug metabolites.