The effects of d- and l-fenfluramine (and their interactions with d-amphetamine) on cortisol secretion
- 1 January 1993
- journal article
- clinical trial
- Published by Wolters Kluwer Health in International Clinical Psychopharmacology
- Vol. 8 (3) , 139-142
- https://doi.org/10.1097/00004850-199300830-00001
Abstract
Twelve normal weight healthy male volunteers participated in a double-blind, placebo-controlled trial of the effects of d- and l-fenfluramine, d-amphetamine, and the interactions between the two isomers of fenfluramine with amphetamine, on cortisol secretion. d-Fenfluramine and d-amphetamine in combination produced the greatest cortisolaemic effect, suggesting that they act by differing neurochemical pathways. d-Fenfluramine produced a significant effect, but l-fenfluramine produced little effect, suggesting that the cortisol-releasing properties of racemic fenfluramine reside in the d-isomer.Keywords
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