The Epithelioneural Bodies

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Abstract
Epi-thelioneural bodies are defined as cellular associations in which there is an intimate relationship of epithelial and neural elements. The cell complexes discussed are, the paraganglia, neuro-entoblastic, and neuro-mesoblastic bodies. The true paraganglia originate from the neural crest as demonstrated in embryologic studies, and give a positive Henle reaction with chrome salts or iodates. The Henle, or "chromaffine" reaction is of itself no criterion for a nervous origin, since it is not restricted to such cells, and a negative reaction may be registered by the cells in certain secretory phases. The glomus coccygeum, vagal masses, and glomus coroticum are listed as neuroepithelial associations of doubtful origin. In sympathico-insular, human appendicular-neural, neuro-hepatic, and duodenal epithelioneural complexes, the epithelial elements arise from the entoblast. In 3 of these, evidence of transformation of epithelial into nerve cells has been demonstrated.