Initial results from a PET/planar small animal imaging system
Open Access
- 1 June 1999
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Nuclear Science
- Vol. 46 (3) , 571-575
- https://doi.org/10.1109/23.775581
Abstract
A pair of stationary, opposed scintillation detectors in time coincidence is being used to create planar projection or tomographic images of small animals injected with positronemitting radiotracers. The detectors are comprised of arrays of individual crystals of bismuth germanate coupled to position-sensitive photomultiplier tubes. The system uses FERA (LeCroy Research Systems) charge-sensitive ADCs and a low cost digital YO board as a E R A bus-to-host bridge. In projection mode, the animal is placed within the 55 mm x 45 mm useful field-of-view of the detectors and images are formed from coincidence lines that fall close to the normals of both detectors. In tomographic mode, the animal is placed on a rotation stage between the detectors and rotated around a vertical axis to acquire all possible lines-of-response. Tomographic images are then reconstructed from those lines falling within a user-specified angle of each detector normal. In mice, the system is capable of high-speed, whole-body dynamic projection imaging, and whole body tomographic imaging of slowly varying tracer distributions. An ECG gating capability is also available for evaluating cardiac function. This system is currently being used to study tracer transport in normal and genetically engineered mice.PublicadKeywords
This publication has 13 references indexed in Scilit:
- Investigation of GSO, LSO and YSO scintillators using reverse avalanche photodiodesIEEE Transactions on Nuclear Science, 1998
- Development of a novel radiation imaging detector system for in vivo gene imaging in small animal studiesIEEE Transactions on Nuclear Science, 1998
- Cleft palate in mice with a targeted mutation in the γ-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67Proceedings of the National Academy of Sciences, 1997
- Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stressInternational Journal of Radiation Oncology*Biology*Physics, 1997
- Evaluation of 3D reconstruction algorithms for a small animal PET cameraIEEE Transactions on Nuclear Science, 1997
- Investigation of LSO crystals for high spatial resolution positron emission tomographyIEEE Transactions on Nuclear Science, 1997
- The design of an animal PET: flexible geometry for achieving optimal spatial resolution or high sensitivityIEEE Transactions on Medical Imaging, 1997
- Folate receptor imaging with 125I labeled folic acid with a whole body small animal imaging device built with plastic scintillating optical fibersNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1995
- Evaluation of cerium doped lutetium oxyorthosilicate (LSO) scintillation crystals for PETIEEE Transactions on Nuclear Science, 1993
- Cerium-doped lutetium oxyorthosilicate: a fast, efficient new scintillatorIEEE Transactions on Nuclear Science, 1992