Abstract
A model system in which helper T cells are required to mount a primary antiviral cytolytic T lymphocyte response was described. The radioresistant helper cell was found in the spleens of mice that were immunized s.c. with infuenza viruses 6-8 days previously. These helper cells appear to be type specific but cross-reactive among the subtypes of influenza A viruses. The phenotypes of the interacting cell populations were determined.

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