Frequency Potentiation and Paired Stimulation Potentiation of Cat Papillary Muscles in Calcium and in Strontium Containing Media

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Abstract
The substitution of Ca ions by Sr abolishes postextrasysto-lic and paired stimulation potentiation in isolated cat papillary muscles. Frequency potentiation is the only remaining adaptation mechanism to increased frequencies, regardless whether they are regular or irregular. Hence, Sr can substitute for Ca in its cumulative effect on the contractile elements, but not in regard to its property adapting contractility from beat-to-beat. Postextrasystolic and paired stimulation potentiation are fully Ca dependent, and must be distinguished from a simple frequency potentiation.

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