Circulatory Phenomena During Anoxia in the Newborn Lamb

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Abstract
Newborn lambs were delivered by hysterotomy, their respiratory passages occluded, and their umbilical cords ligated. Lead II electrocardiographs and aortic blood pressures were taken during the increasing asphyxia. Precipitous fall in heart rate resulting from heart block occurred within two minutes of cord ligation. Thereafter progressive fall in heart rate, systolic blood pressure, and pulse pressure occurred. In sequence, the electrocardiogram revealed heart block, return of slow sinus rhythm, lowering of T wave and shortening of QT interval, and terminal loss of P wave with development of bizarre broad QRS complex, low ST takeoff and loss of definition of the QS endpoint.

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