Red blood cell targeting to collagen‐coated surfaces
- 18 April 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 154 (2) , 257-261
- https://doi.org/10.1016/0014-5793(83)80160-4
Abstract
The interaction of human red blood cells carrying antihuman collagen antibody with collagen-coated surfaces was studied. Avidin was used as bifunctional crosslinking agent for the attachment of antibody to the red blood cell surface. Antibody-carrying red blood cells efficiently and specifically bound to collagen-coated surface covering a significant part of the surface. The components of normal blood had an insignificant effect on red blood cell binding. A model of drug targeting to the injured sites(s) of blood vessel wall is proposed.Keywords
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